Fig. 5: SiRNA modulated the function of Cx43 channels and attenuated NRK-52E cells damage caused by H24R4, LPS, or a combination of H24R4 and LPS. | Cell Death & Disease

Fig. 5: SiRNA modulated the function of Cx43 channels and attenuated NRK-52E cells damage caused by H24R4, LPS, or a combination of H24R4 and LPS.

From: Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation

Fig. 5

a, b Specific siRNA–Cx43 downregulated Cx43 expression and function. n = 5, *P < 0.05 vs control. The arrows were the donor cells. c, d Specific siRNA increased NRK-52E cell growth, but decreased LDH release when exposed to H24R4, LPS (5 μg/ml, 24 h), or a combination of H24R4 and LPS. n = 5, *P < 0.05 vs control; #P < 0.05 vs the H24R4 group; △P < 0.05 vs the LPS group; ▲P < 0.05 vs H24R4 + LPS group

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