Fig. 7: Cx43 channel inhibition attenuated oxidative stress and inflammatory reaction via depressing ROS in vitro. | Cell Death & Disease

Fig. 7: Cx43 channel inhibition attenuated oxidative stress and inflammatory reaction via depressing ROS in vitro.

From: Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation

Fig. 7

a Gap26 application (300 μM, 1 h) attenuated H24R4, LPS, or a combination of H24R4 and LPS-induced 15-F2t-Isoprostane (15-F2t-Isop), malondialdehyde (MDA), and H2O2 increase, but increased SOD production. b Gap26 application (300 μM, 1 h) attenuated H24R4, LPS, or a combination of H24R4 and LPS-induced IL-1β, IL-6, IL-8, and TNF-α increase. c NAC application (10 mM, 1 h) attenuated H24R4, LPS, or a combination of H24R4 and LPS-induced 15-F2t-Isop, MDA, and H2O2 increase, but increased SOD production. d NAC application (10 mM, 1 h) attenuated H24R4, LPS, or a combination of H24R4 and LPS-induced IL-1β, IL-6, IL-8, and TNF-α increase. n = 5–7, *P < 0.05 vs control; #P < 0.05 vs the H24R4 group; △P < 0.05 vs the LPS group; ▲P < 0.05 vs H24R4 + LPS group. Vehicle control of Gap26 was DMSO, which had no significant effects on the above-mentioned parameters (data not shown)

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