Fig. 7: miR-3163 enhances the antitumor effect of sorafenib on the intrahepatic growth of MHCC97-H cells in the liver of nude mice by targeting ADAM-17. | Cell Death & Disease

Fig. 7: miR-3163 enhances the antitumor effect of sorafenib on the intrahepatic growth of MHCC97-H cells in the liver of nude mice by targeting ADAM-17.

From: MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents

Fig. 7

MHCC97-H cells transfected with vectors (control miRNA, miR-3163, miR-3163 + ADAM-17Mut, or miR-3163 + NICD) were injected into the liver of nude mice through hepatic portal vein injection. Mice received oral administration of 2 mg/kg dose of sorafenib. After treatment, the mice underwent microPET screening and were harvested to collect tumor tissues. The results are shown as images of micro-PET or quantitative analysis (a), images of livers with lesions (b), represented images of livers with lesions from each group (c), relative radio-activation of livers (d), or the relative area of lesions (e). *P < 0.05

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