Fig. 7: Cav-1 induces the resistance of PCa cells to chemotherapy or radiotherapy.
From: The paracrine induction of prostate cancer progression by caveolin-1
a The effect of NFκB inhibitor (BAY, 5 µm) on the sensitivity of LNCaP (Vc vs. Cav1OE) cells exposed to different concentrations of Docetaxel was determined by MTT assay 48 h post treatment. b The effect of NFκB inhibitor (BAY, 5 µm) on the sensitivity of WT LNCaP cells incubated with exosomes from various sources and different concentrations of Docetaxel was determined by MTT assay 48 h post treatment. c The effect of radiation (0–6 Gy) on cell survival of LNCaP (Vc vs. Cav1OE) or Du145 (Vc vs. shCav1) was determined 14 days post radiation. d The effect of radiation (0–6 Gy) on cell survival of WT LNCaP treated with exosomes from various sources was determined 14 days post radiation. All data were shown as mean ± SD (n > 10), *P < 0.5, **P < 0.01, ***P < 0.001
