Fig. 3: Genetic inhibition of NFAT5 suppresses PDAC cell growth both in vivo and in vitro. | Cell Death & Disease

Fig. 3: Genetic inhibition of NFAT5 suppresses PDAC cell growth both in vivo and in vitro.

From: Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1

Fig. 3

a Relative mRNA and protein levels of NFAT5 in six pancreatic cancer cell lines. b The mRNA and protein expression of NFAT5 in NFAT5 knockdown AsPC-1 and BxPC-3 treated with shRNA. c The CCK-8 assay showed that NFAT5 knockdown in AsPC-3 and BxPC-3 cells resulted in suppressed proliferation capability. d The colony formation ability was restrained in NFAT5 knockdown PDAC cells. e Representative bioluminescence photograph of mice orthotopically implanted with luciferase-expressing AsPC-1 cells with or without NFAT5 knockdown. f IHC staining of PCNA in mice orthotopically implanted tissue. *P < 0.05, **P < 0.01, ****P < 0.0001.

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