Fig. 5: RIP3ko protects from MPTP-driven DNA fragmentation, 4-HNE accumulation, caspase-3 activation and increased BAX expression detected in Wt mice.
From: Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease
a Representative images of TUNEL-positive apoptotic nuclei in the SN of control- and MPTP-injected mice from both genotypes and respective quantification. Scale bar, 40 μm. b Representative WB of soluble proteins from SN of controls and MPTP-injected mice from both genotypes and respective densitometric analysis. c BAX/Bcl-2 ratio and caspase-3/7 activity were determined in protein samples from SN of control– and MPTP-injected mice from both genotypes. Values represent mean ± SEM of 6–7 mice per group. *p < 0.05 from control Wt mice and §p < 0.05 from MPTP-injected Wt mice. c-Casp3: cleaved caspase-3
