Fig. 5: Overexpression of LINC01111 can rescue the effects of PC cells induced by SPAK/JNK inhibition. | Cell Death & Disease

Fig. 5: Overexpression of LINC01111 can rescue the effects of PC cells induced by SPAK/JNK inhibition.

From: Long noncoding RNA LINC01111 suppresses pancreatic cancer aggressiveness by regulating DUSP1 expression via microRNA-3924

Fig. 5

a The effect of the SAPK/JNK signaling pathway inhibitor SP600125 detected by western blotting. b The CCK-8 assay comparing cell proliferation was performed in PC cells when treated differently (NControl, NControl + SP600125, LINC01111-UP, LINC01111-UP+si-DUSP1). All experiments were performed in triplicate, and data are presented as mean ± SD. *p < 0.05, **p < 0.01. c Transwell assay evaluating cell invasion and migration was performed in PC cells when treated differently. All experiments were performed in triplicate, and data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. d Western blotting showing the expression change of proteins involved in the SAPK/JNK signaling pathway when treated differently.

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