Fig. 2: Effect of m6A DNA and its modulators in leukocytes and vasculature of mice with atherosclerosis (AS) induced by a western diet (WD). | Cell Death & Disease

Fig. 2: Effect of m6A DNA and its modulators in leukocytes and vasculature of mice with atherosclerosis (AS) induced by a western diet (WD).

From: Association of N6-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts

Fig. 2

a Overall leukocyte m6A levels in male ApoE−/− mice (8 weeks old) fed a WD (n = 13) and normal diet (ND, n = 12) for 6 months. b Spearman correlation coefficient for leukocyte m6A level correlated with plaque thickness of aortic root (n = 15). c mRNA expression of N6AMT and ALKBH1 in leukocytes (n = 6 for ND; n = 8 for WD). d–g Representation immunofluorescence co-staining and quantification of ALKBH1 (d, e) and N6AMT1 (f, g) in endothelial cells (ECs) of frontal sections from aortic root (n = 10 for ND; n = 15 for WD). Scale bar: 50 µm. von Willebrand factor (vWF) was the EC marker. Data are mean ± SD and were compared by unpaired t test in (a, c, b, and g). Rel. Relative, DAPI was a nuclear marker.

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