Table 1 Linear regression analysis of association of clinical factors and DNA methylation adjusted for age and sex.

From: Association of N6-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts

Clinical factors

m6A DNA

5mC DNA

β

95% CI

P

β

95% CI

P

Plaque size (mm3)

−0.289

−0.825 to −0.068

<0.001

−0.076

−0.347 to 0.127

0.337

CIMT (mm)

−0.443

−1.124 to −0.103

<0.001

−0.065

−0.170 to 0.115

0.396

Hcy (µmol/L)

−0.162

−0.423 to −0.024

0.023

−0.115

−0.521 to −0.025

0.031

VB12 (pg/ml)

0.171

0.012 to 0.424

0.017

−0.025

−0.103 to 0.087

0.730

Folic acid (ng/ml)

0.082

−0.143 to 0.247

0.259

0.031

−0.129 to 0.294

0.662

Albumin (g/L)

0.257

0.019 to 0.532

<0.001

−0.008

−0.303 to 0.387

0.911

LDL (mmol/L)

−0.175

−0.494 to −0.089

0.023

0.020

−0.126 to 0.272

0.776

TG (mmol/L)

0.057

−0.197 to 0.202

0.426

−0.089

−0.301 to 0.251

0.208

HDL (mmol/L)

0.084

−0.102 to 0.347

0.235

−0.026

−0.378 to 0.324

0.706

ALT (U/L)

−0.077

−0.236 to 0.173

0.282

0.044

−0.208 to 0.325

0.530

AST (U/L)

−0.062

−0.279 to 0.368

0.383

0.019

−0.107 to 0.305

0.788

ALP (U/L)

−0.035

−0.207 to 0.159

0.616

0.040

−0.246 to 0.301

0.561

Urea (mmol/L)

−0.057

−0.349 to 0.267

0.420

−0.061

−0.142 to 0.108

0.378

UA (µmol/L

0.115

−0.134 to 0.360

0.103

0.107

−0.214 to 0.480

0.125

Apo A (g/L)

0.075

−0.141 to 0.342

0.328

−0.040

−0.237 to 0.253

0.592

Apo B (g/L)

−0.072

−0.416 to 0.504

0.332

0.035

−0.241 to 0.358

0.635

TC (mmol/L)

0.051

−0.312 to 0.465

0.487

−0.042

−0.475 to 0.349

0.557

  1. CIMT carotid intima-media thickness, Hcy homocysteine, VB12 vitamin B12, LDL low-density lipoprotein, TG triglycerides, HDL high-density lipoprotein, ALT alanine aminotransferase, AST aminotransferase, ALP alkaline phosphatase, Apo A apolipoprotein A, Apo B apolipoprotein B, TC total cholesterol
  2. The bold, significant difference
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