Fig. 4: Downregulation of SKA3 affects the cell cycle in HCC cells.
From: SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma
a GSEA analysis suggested that SKA3 is related to cell cycle in HCC using TCGA datasets. b Depletion of SKA3 triggered G2 block in LM3 and Huh7 cells. c Correlation analysis showed that SKA3 is strongly related with CDK1, CDK2, CDK4, CCNA2, and CCNE2. d, e Western blot analysis suggested that knockdown of SKA3 upregulated CDK2, CDK4, CCNA2, and CCNE2. All *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
