Table 2 Univariate and multivariate Cox regression analysis of risk factors associated with overall survival.
From: SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P-Value | HR | 95% CI | P-Value | |
SKA3 expression (high vs. low) | 2.239 | 1.574–3.187 | 7.59e−06 | 1.299 | 0.829–2.034 | 0.25 |
Sex (male vs. female) | 0.935 | 0.67–1.305 | 0.69 | |||
Age (≥50 vs. <50) | 0.899 | 0.659–1.226 | 0.50 | |||
HBsAg (positive vs. negative) | 0.944 | 0.671–1.329 | 0.74 | |||
AFP (≥200 ng/ml vs. <200 ng/ml) | 1.797 | 1.279–2.525 | 7.31e−04 | 1.048 | 0.692–1.586 | 0.83 |
Tumor size (>5 cm vs. ≤5 cm) | 2.441 | 1.742–3.421 | 2.19e−07 | 1.688 | 1.136–2.509 | 0.0095 |
Tumor nodule number (multiple vs. single) | 1.797 | 1.284–2.514 | 6.27e−04 | 1.086 | 0.744–1.585 | 0.67 |
Cancer embolus (presence vs. absence) | 2.875 | 2.035–4.061 | 2.07e−09 | 1.878 | 1.231–2.866 | 0.0035 |
TNM stage (late vs. early) | 2.095 | 1.485–2.956 | 2.5e−05 | 1.209 | 0.804–1.818 | 0.36 |
Differentiation grade (poor vs. well) | 1.545 | 1.08–2.211 | 0.017 | 0.970 | 0.648–1.452 | 0.88 |
