Table 3 Univariate and multivariate Cox regression analysis of risk factors associated with disease-free survival.
From: SKA3 Promotes tumor growth by regulating CDK2/P53 phosphorylation in hepatocellular carcinoma
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P-Value | HR | 95% CI | P-Value | |
SKA3expression (high vs. low) | 2.107 | 1.54–2.883 | 3.18e−06 | 1.501 | 1.017–2.216 | 0.04 |
Sex (male vs. female) | 1.107 | 0.818–1.498 | 0.51 | |||
Age (≥50 vs. <50) | 0.912 | 0.67–1.24 | 0.56 | |||
HBsAg (positive vs. negative) | 1.441 | 1.04–1.998 | 0.028 | 1.745 | 1.234–2.466 | 0.0016 |
AFP (≥200 ng/ml vs. <200 ng/ml) | 1.623 | 1.184–2.225 | 2.63e−03 | 1.042 | 0.707–1.536 | 0.83 |
Tumor size (>5 cm vs. ≤5 cm) | 2.098 | 1.549–2.84 | 1.66e−06 | 1.667 | 1.174–2.365 | 0.0042 |
Tumor nodule number (multiple vs. single) | 1.517 | 1.114–2.066 | 8.13e−03 | 1.077 | 0.76–1.525 | 0.68 |
Cancer embolus (presence vs. absence) | 2.420 | 1.766–3.316 | 3.88e−08 | 2.002 | 1.046–3.832 | 0.0362 |
TNM stage (late vs. early) | 1.451 | 1.049–2.008 | 0.025 | 1.051 | 0.715–1.547 | 0.80 |
Differentiation grade (poor vs. well) | 1.480 | 1.064–2.058 | 0.02 | 0.909 | 0.62–1.333 | 0.62 |
