Fig. 2: RASSF1A as a master-organizer of epithelial cell differentiation maintenance and cell trafficking. | Cell Death & Disease

Fig. 2: RASSF1A as a master-organizer of epithelial cell differentiation maintenance and cell trafficking.

From: RASSF1A, puppeteer of cellular homeostasis, fights tumorigenesis, and metastasis—an updated review

Fig. 2

RASSF1A influences the cytoskeleton directly (through HDAC6 inhibition37) or via Rho GTPases or/and LIMK/Cofilin signaling to promote YAP cytoplasmic accumulation in inactive form56. Furthermore, RASSF1A enhances stabilization of focal adhesion and cell–cell junctions56. RASSF1A stabilizes the microtubules through its inhibitory action on HDAC6 deacetylase37 to build a long, reliable tracks for MT-dependent transport85. Furthermore, RASSF1A-associated MTs acetylation is necessary for the centrosome and Golgi organization39,40,41,93. RASSF1A is also able to influence LIMK/Cofilin activity56 and Rab GTPase signaling86, which play crucial roles in intracellular transport and exosome release87,88.

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