Fig. 2: OPCs transplantation attenuated infarct volume and brain edema and improved neurological outcomes after MCAO. | Cell Death & Disease

Fig. 2: OPCs transplantation attenuated infarct volume and brain edema and improved neurological outcomes after MCAO.

From: Oligodendrocyte precursor cells transplantation protects blood–brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling

Fig. 2

a Cresyl violet staining showed the infarction after MCAO in Sham, Stroke + PBS and Stroke + OPC groups. Bar graphs indicated that OPCs transplantation reduced infarct volume and edema formation. Scale bar = 1 mm. b Bar graph of neurological scores. c Bar graph of latency to fall. d Trace pictures and the bar graph of step through test showed that OPCs ameliorated the cognitive damage caused by ischemic stroke. Data are mean ± SD, n = 8–10 per group. *p < 0.05, ***p < 0.001, as compared with Stroke + PBS group. #p < 0.05, ###p < 0.001, as compared with Sham group. S + P: Stroke + PBS; S + O: Stroke + OPC.

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