Fig. 5: Inhibition of β-catenin aggravated the neurological outcomes, infarct volume, edema formation, and BBB disruption. | Cell Death & Disease

Fig. 5: Inhibition of β-catenin aggravated the neurological outcomes, infarct volume, edema formation, and BBB disruption.

From: Oligodendrocyte precursor cells transplantation protects blood–brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling

Fig. 5

Bar graphs indicated the inhibition of β-catenin hindered the beneficial effects of OPCs in neurological scores (a), infarct volume (b), and edema formation (c), respectively. d IgG staining showed the IgG leakage in Stroke + PBS, Stroke + OPC, and Stroke + OPC + XAV-939 groups after 3 days following MCAO. e Images showed the β-catenin (green)/CD31(red) immunofluorescence staining in above three groups. XAV-939 decreased the expression of β-catenin in endothelial cells. f Immunofluorescent images of claudin-5 (green) and bar graph displayed XAV-939 reversed the claudin-5 upregulation caused by OPCs. Data are mean ± SD, n = 6–8 per group, *p < 0.05, ***p < 0.001, as compared with Stroke + OPC group. Scale bar = 50 µm (e) and 100 µm (f). S + P: Stroke + PBS; S + O: Stroke + OPC; S + O + X: Stroke + OPC + XAV-939.

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