Fig. 5: miR-26a/b suppress cytokines via targeting CD38.
From: MicroRNA-26a/b have protective roles in oral lichen planus
a IFNγ, TNFα, IL-2, and IL-12 levels detected by real-time PCR in HOKs after CD38 plasmids transfection. (b) qPCR showing IFNγ, TNFα, IL-2 and IL-12 levels in activated CD4+ T cells or LPS-stimulated HOKs, following CD38 inhibitor treatment. Real-time PCR analysis of IFNγ, TNFα, IL-2 and IL-12 levels in HOKs during miR-26a (c) or miR-26b (d) mimic treatment with or without CD3 plasmids transfection as indicated. Real-time PCR analysis of IFNγ, TNFα, IL-2, and IL-12 levels in HOKs during miR-26a (e) or miR-26b (f) inhibitor treatment with or without siRNA transfection. *P < 0.05, **P < 0.01, ***P < 0.001 vs. corresponding control; #P < 0.05, ##P < 0.01 vs miR-26a/b mi or In group; n = 3. Ctrl control, mi mimic, In inhibitor.
