Fig. 2: CircCTNNA1 promotes the growth, invasion, and migration of colon cancer cells in vitro. | Cell Death & Disease

Fig. 2: CircCTNNA1 promotes the growth, invasion, and migration of colon cancer cells in vitro.

From: Circular RNA circCTNNA1 promotes colorectal cancer progression by sponging miR-149-5p and regulating FOXM1 expression

Fig. 2

a CircCTNNA1 expression in normal and colon cancer cell lines was measured using qRT-PCR. b, c The effects of overexpression or knockdown of circCTNNA1 in SW620 or SW480 cells were measured using qRT-PCR. d knockdown and overexpression of circCTNNA1 had no effect on the expression level of linear mRNA of CTNNA1. e, f CCK-8 and colony formation assays of colon cancer cells with circCTNNA1 overexpression or knockdown. g, h EdU incorporation assay revealed the changes of DNA synthesis after overexpression or knockdown of circCTNNA1. I, j Transwell and wound-healing assays showed that invasion and migration were significantly increased after circCTNNA1 overexpression, but inhibited after circCTNNA1 knockdown. *p < 0.05, **p < 0.01, ***p < 0.001.

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