Fig. 5: miR-149-5p reverses the oncogenic functions of circCTNNA1. | Cell Death & Disease

Fig. 5: miR-149-5p reverses the oncogenic functions of circCTNNA1.

From: Circular RNA circCTNNA1 promotes colorectal cancer progression by sponging miR-149-5p and regulating FOXM1 expression

Fig. 5

a, b Colony formation assays revealed that cell proliferation affected by circCTNNA1 knockdown or overexpression was reversed by co-transfection with the miR-149-5p inhibitor or mimic. c, e, g EdU, transwell, and wound-healing showed that DNA synthesis, invasion, and migration attenuated by circCTNNA1 knockdown was reversed by co-transfection with the miR-149-5p inhibitor. d, f, h DNA synthesis, invasion and migration augmented by circCTNNA1 overexpression was reversed by co-transfection with the miR-149-5p mimic. Scale bar = 100 µm. *p < 0.05, **p < 0.01, ***p < 0.001.

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