Table 3 Summary of NRF2 associated miRNAs in cancer.

From: Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression

Name	Associated cancer type	Target	Influence to NRF2	Model of evidence	Reference
miR-141	Hepatocellular carcinoma, ovarian cancer	KEAP1	Up	Cell culture	^88,91,92,93
miR-23a	Leukemic	KEAP1	Up	Cell culture, animal models	⁹⁴
miR-432	Esophageal cancer	KEAP1	Up	Cell culture	^92,95
miR-7	Neuroblastoma cells	KEAP1	Up	Cell culture	⁹²
miR-200a	Breast cancer, esophageal cancer, hepatocellular carcinoma, and pancreatic adenocarcinomas	KEAP1,	Up	Cell culture, animal models	^{81,92,96,97,215,216}
miR-155	Lung cancer	NRF2	Up	Cell culture	²¹⁷
miR-101	Hepatocellular carcinoma, prostate cancer	NRF2, SOD1	Up/Down	Cell culture, animal models	^88,105,218
miR-1	Lung cancer, prostate cancer	NRF2, SOD1	Up/Inhibited by NRF2	Cell culture, animal models	^105,107
miR-206	Lung cancer, prostate cancer	NRF2, SOD1	Up/Inhibited by NRF2	Cell culture, animal models	^105,106,107
miR-148b	Endometrial cancer	ERMP1	Down	Cell culture	²¹⁹
miR-129	Esophageal cancer	NRF2	Down	Cell culture, animal models	⁸⁰
miR-129-5a	Esophageal cancer	NRF2	Down	Cell culture, animal models	^80,81
miR-129-5p	Esophageal cancer	NRF2	Down	Cell culture, animal models	⁸⁰
miR-142	Esophageal cancer	NRF2	Down	Cell culture	⁸²
miR-144	Hepatocellular carcinoma, leukemia, hepatocellular carcinoma, neuroblastoma	NRF2	Down	Cell culture	^88,89
miR-144-3p	Melanoma, lung cancer, and acute myeloid leukemia	NRF2	Down	Cell culture	^{86,87,220,221}
miR-153	Neuroblastoma, breast cancer, and oral squamous cell carcinoma	NRF2	Down	Cell culture	^82,90
miR-200c	Lung cancer	NRF2	Down	Cell culture, animal models	²²²
miR-212-3p	Melanoma	NRF2	Down	Cell culture	⁸⁶
miR-23b-3p	Melanoma	NRF2	Down	Cell culture	⁸⁶
miR-27	Neuroblastoma	NRF2	Down	Cell culture, animal models	²²³
miR-28	Breast cancer, esophageal cancer	NRF2	Down	Cell culture	^81,224
miR-340	Hepatocellular carcinoma, esophageal cancer	NRF2	Down	Cell culture	^85,88,92
miR-34a	Breast cancer, colon cancer, ovarian cancer, and lung cancer	NRF2	Down	Cell culture	^225,226
miR-450	Esophageal cancer	NRF2	Down	Cell culture	⁸³
miR-450a	Esophageal cancer	NRF2	Down	Cell culture, animal models	^80,81
miR-495	Nonsmall-cell lung cancer	NRF2	Down	Cell culture	²²⁷
miR-507	Esophageal cancer	NRF2	Down	Cell culture, animal models	^80,81,84
miR-634	Esophageal cancer	NRF2	Down	Cell culture, animal models	^80,81,85
miR-93	Pancreatic adenocarcinomas, breast cancer	NRF2	Down	Cell culture, animal models	^97,221
miR-93-5p	Melanoma	NRF2	Down	Clinical samples	⁸⁶
miR-125b	Acute myelocytic leukemia, oral squamous cell carcinoma, and renal cancer	NRF2	Down/Induced by NRF2	Cell culture, animal models	^98,99,228
miR-181c	Colorectal cancer	–	Inhibited by NRF2	Cell culture, animal models	¹⁰²
miR-378	Mucoepidermoid carcinoma	–	Inhibited by NRF2	Cell culture, animal models	¹⁰³
miR-122	Hepatocellular carcinoma	–	Inhibited by NRF2	Cell culture	¹⁰⁴
miR-17-5p	Multiple myeloma	–	Inhibited by NRF2	Cell culture, animal models	⁶⁶
miR-29B1	Acute myelocytic leukemia	–	Induced by NRF2	Cell culture	⁹⁸
miR-129-3p	Hepatocellular carcinoma	–	Induced by NRF2	Cell culture, animal models	¹⁰⁰
miR-380-3p	Neuroblastoma	–	Induced by NRF2	Cell culture, animal models	¹⁰¹

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Table 3 Summary of NRF2 associated miRNAs in cancer.

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