Table 4 Summary of ROS associated miRNAs in cancer.

From: Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression

Name	Associated cancer type	Target	Influence to ROS	Model of evidence	Reference
miR-124	Non-small cell lung cancer	TXNRD1	Up	Cell culture	¹²⁰
miR-125a	Osteosarcoma	Estrogen-related receptor alpha	Up	Cell culture	²²⁹
miR-128a	Medulloblastoma	BMI-1	Up	Cell culture	²³⁰
miR-139-5p	Breast cancer	Unknown	Up	Cell culture, animal models	²³¹
miR-143	Colorectal cancer	SOD1	Up	Cell culture	¹²¹
miR-146a	Lung cancer, ovarian Cancer	Catalase, SOD2	Up	Cell culture, animal models	^117,118
miR-146b-5p	Leukemic	Unknown	Up	Cell culture	²³²
miR-15	Colorectal cancer, cancer stem cells	C-MYC	Up	Cell culture, animal models	²³³
miR-155	Glioma, pancreatic cancer	MAPK13, MAPK14, and Foxo3a	Up	Cell culture, animal models	^234,235
miR-15a-3p	Lung cancer	P53	Up	Cell culture	²³⁶
miR-16	Colorectal cancer, cancer stem cells	C-MYC	Up	Cell culture, animal models	²³³
miR-186	Colorectal cancer	CKII	Up	Cell culture	²³⁷
miR-193a-3p	Glioma	γH2AX	Up	Cell culture	²³⁸
miR-210	Cancer stem cells, glioma	P53	Up	Cell culture, animal models	²³⁹
miR-212	Colorectal cancer	MnSOD	Up	Clinical samples	²⁴⁰
miR-216b	Colorectal cancer	CKII	Up	Cell culture	²³⁷
miR-22	Hepatocellular carcinoma	SIRT-1	Up	Cell culture	²⁴¹
miR-223	Breast cancer	HAX-1	Up	Cell culture	²⁴²
miR-23b-3p	Acute myeloid leukemia	PrxIII	Up	Cell culture	²⁴³
miR-25-5p	Colorectal cancer	SOX10	Up	Cell culture	²⁴⁴
miR-26a-5p	Acute myeloid leukemia	PrxIII	Up	Cell culture	²⁴³
miR-26b	Small cell lung cancer	Myeloid cell leukemia 1 protein	Up	Cell culture, animal models	²⁴⁵
miR-30	Gastric cancer	P53	Up	Cell culture	²⁴⁶
miR-337-3p	Colorectal cancer	CKII	Up	Cell culture	²³⁷
miR-34c	Nonsmall cell lung cancer	HMGB1	Up	Cell culture	²⁴⁷
miR-371-3p	Lung cancer	PRDX6	Up	Cell culture, animal models	²⁴⁸
miR-422a	Gastric cancer	PDK2	Up	Cell culture, animal models	²⁴⁹
miR-4485	Breast cancer	Mitochondrial protein	Up	Cell culture, animal models	¹³³
miR-4673	Lung cancer	8-Oxoguanine-DNA Glycosylase-1	Up	Cell culture	²⁵⁰
miR-504	Lung cancer	P53	Up	Cell culture	²⁵¹
miR-506	Lung cancer	P53, NF-κB	Up	Cell culture, animal models	²⁵²
miR-509	Breast cancer	P53	Up	Cell culture	²⁵³
miR-526b	Breast cancer	Thioredoxin Reductase 1	Up	Cell culture	¹¹⁹
miR-551b	Lung cancer	MUC1	Up	Cell culture	²⁵⁴
miR-655	Breast cancer	Thioredoxin Reductase 1	Up	Cell culture	¹¹⁹
miR-661	Colorectal cancer	Hexose-6-phosphate dehydrogenase, pyruvate kinase M2	Up	Cell culture	²⁵⁵
miR-760	Colorectal cancer	CKII	Up	Cell culture	²³⁷
miR-92	Hepatocellular carcinoma	Unknown	Up	Clinical samples	²⁵⁶
miR-128	Glioma, hepatocellular carcinoma	PKM2	Up/Down	Cell culture	²⁵⁷
miR-145	Colorectal cancer, hepatocellular carcinoma	SOD1, PKM2	Up/Down	Cell culture	^121,258
miR-211	Myeloma, oral carcinoma	PRKAA1, TCF12	Up/Down	Cell culture, animal models	^259,260
miR-222	Hepatocellular carcinoma, breast cancer	NF-κB, TGF-β	Up/Down	Cell culture, animal models	^261,262
miR-23a/b	Myeloma, renal cancer	C-MYC, POX	Up/Down	Cell culture, animal models	^263,264
miR-29	Ovarian cancer, lung cancer, and lymphoma	C-MYC, SIRT1	Up/Down	Cell culture, animal models	^265,266
miR-34a	Gastric cancer, glioma	NOX2	Up/Down	Cell culture	²⁶⁷
Let-7	Hepatocellular carcinoma, prostate cancer, and pancreatic cancer	Heme oxygenase-1, P53	Up/Down	Cell culture, animal models	^123,268
miR-33a	Glioma, hepatocellular carcinoma	SIRT6	Up/Down	Cell culture, animal models	²⁶⁹
miR-221	Hepatocellular carcinoma, breast cancer	NF-κB, TGF-β, and DICER	Up/Down/Induced by ROS	Cell culture, animal models	^261,262,270
miR-21	Lung cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, ovarian cancer, and prostate cancer	SOD, MAPK, SOD2, Glucose, NFκB, STAT3, POX, and PDCD4	Up/Down/Induced by ROS	Cell culture, animal models	^{108,112,114,271}
miR-17-92	Gastric cancer, lung cancer	C-MYC, P53, and NFκB	Up/Down/Inhibited by ROS	Cell culture	^137,272,273
miR-181	Hepatocellular carcinoma, uterine leiomyoma	Unknown	Up/Induced by ROS	Cell culture	^132,274
miR-200	Breast cancer, cancer stem cells, hepatocellular carcinoma, and lung cancer	P53, PRDX2, GAPB/NRF2, SESN1	Up/Induced by ROS	Cell culture, animal models	^{222,275,276,277}
miR-34	Cancer stem cells, bladder cancer, lung cancer	C-MYC, P53	Up/Induced by ROS	Cell culture	^278,279
miR-182	Uterine leiomyoma, lung cancer	PDK4	Up/Induced by ROS	Cell culture, animal models	^132,133
miR-199	Gastric cancer, ovarian cancer	DNMT1	Up/Inhibited by ROS	Cell culture	¹³⁴
miR-20a	Breast cancer, pancreatic cancer	BECN1, ATG16L1, and SQSTM1	Up/Inhibited by ROS	Cell culture, animal models	^136,280
miR-125b	Hepatocellular carcinoma, ovarian cancer, and breast cancer	Hexokinase 2, DNMT1, and HAX-1	Up/Inhibited by ROS	Cell culture, animal models	^228,281
miR-1246	Breast cancer	NF-κB, TGF-β	Down	Cell culture	¹²⁴
miR-137	Ovarian cancer	C-MYC	Down	Cell culture, animal models	¹²⁵
miR-193b	Liposarcoma	Antioxidant methionine sulfoxide reductase A	Down	Cell culture, animal models	¹²⁷
miR-199a-3p	Testicular cancer	Transcription factor specificity protein 1	Down	Cell culture	¹²⁶
miR-26a	Hepatocellular carcinoma	Triglyceride, totalcholesterol, malondialdehyde	Down	Cell culture	¹²⁸
miR-30c-2-3p	Breast cancer	NF-κB, TGF-β	Down	Cell culture	²⁸²
miR-346	Ovarian cancer	GSK3B	Down	Cell culture	²⁸³
miR-373	Breast cancer	NF-κB, TGF-β	Down	Cell culture, animal models	¹²³
miR-520	Breast cancer	NF-κB, TGF-β	Down	Cell culture, animal models	¹²³
miR-7	Nonsmall cell lung cancer	MAFG	Down	Cell culture	²⁸⁴
miR-885-5p	Hepatocellular carcinoma	TIGAR	Down	Cell culture	²⁸⁵
miR-99a	Lung cancer	NOX4	Down	Cell culture, animal models	¹²²
miR-133a	Rhabdomyosarcoma	9	Induced by ROS	Cell culture, animal models	¹²⁹
miR-150-3p	Hepatocellular carcinoma	–	Induced by ROS	Cell culture	¹³⁰
miR-1915-3p	Hepatocellular Carcinoma	–	Induced by ROS	Cell culture	¹³⁰
miR-206	Rhabdomyosarcoma	–	Induced by ROS	Cell culture, animal models	¹³¹
miR-34a-3p	Hepatocellular carcinoma	–	Induced by ROS	Cell culture, animal models	¹²⁹
miR-34a-5p	Hepatocellular carcinoma	–	Induced by ROS	Cell culture	¹³⁰
miR-638	Hepatocellular carcinoma	–	Induced by ROS	Cell culture	¹³⁰
miR-125	Gastric cancer	–	Inhibited by ROS	Cell culture	¹³⁴
miR-145-5p	Gastric cancer	–	Inhibited by ROS	Cell culture, animal models	¹³⁵
miR-17-5p	Pancreatic cancer	–	Inhibited by ROS	Cell culture, animal models	¹³⁶
miR-27a	Pancreatic cancer, colorectal cancer	–	Inhibited by ROS	Cell culture, animal models	²⁸⁶
miR-328	Gastric cancer	–	Inhibited by ROS	Cell culture, animal models	²⁸⁷
miR-329	Breast cancer	–	Inhibited by ROS	Cell culture, animal models	²⁸⁸
miR-362-3p	Breast cancer	–	Inhibited by ROS	Cell culture, animal models	²⁸⁸

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Table 4 Summary of ROS associated miRNAs in cancer.

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