Fig. 2: α-LA reduces TAC-induced cardiomyocyte apoptosis and cardiac fibrosis in WT mice. | Cell Death & Disease

Fig. 2: α-LA reduces TAC-induced cardiomyocyte apoptosis and cardiac fibrosis in WT mice.

From: Alpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling

Fig. 2

a Terminal dexynucleotidyl transferase (TdT)-mediated dUTP nick end labeling staining(TUNEL, 400×, scale bar = 20 μm); b quantitative analysis of myocardial apoptosis (n = 6 mice per group); c Western blots of cleaved caspase 3, Bax, Bcl-2, and β-actin (loading control); d–f Quantitative analysis of expressions of cleaved caspase 3/β-actin, Bax/β-actin, Bcl-2/β-actin (n = 6 mice per group); g Masson’s Trichome staining (scale bar = 100 μm); h quantitative analysis of myocardial fibrosis (n = 6 mice per group). Mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Statistical analysis was carried out by a one-way ANOVA analysis followed by Tukey’s test for post hoc analysis.

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