Fig. 6: FXR inhibits colorectal tumorigenesis by regulating SHP expression.
From: Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
SHP expression in FXR-knockdown HT-29 and Caco-2 cells (a) or FXR-overexpressing SW480 and HCT116 cells (b) detected by western blotting analysis. c Quantitative analysis of SHP expression in FXR-knockdown HT-29 and Caco-2 cells or FXR-overexpressing SW480 and HCT116 cells. d SHP expression in FXR-knockdown HT-29 and Caco-2 cells or FXR-overexpressing SW480 and HCT116 cells detected by real-time PCR. e The effect of SHP overexpression on cell cycle- and EMT-related protein levels of FXR-knockdown HT-29 and Caco-2 cells detected by western blotting analysis. f The effect of SHP knockdown on cell cycle- and EMT-related protein levels of FXR-overexpressing SW480 and HCT116 cells detected by western blotting analysis. All data are the mean ± SD of three independent experiments. *P < 0.05.
