Fig. 5: AC104041.1 promotes HNSCC tumorigenesis through activation of Wnt2B/β-catenin pathway. | Cell Death & Disease

Fig. 5: AC104041.1 promotes HNSCC tumorigenesis through activation of Wnt2B/β-catenin pathway.

From: Antisense oligonucleotides targeting lncRNA AC104041.1 induces antitumor activity through Wnt2B/β-catenin pathway in head and neck squamous cell carcinomas

Fig. 5

a Cell proliferation were assessed in AC104041.1 knockdown or combined with miR-6817-3p inhibitors (n = 5). Data are presented as the mean values ± SEM, the experiment was repeated three times, ***P < 0.001, compared with control cells (two-way ANOVA). b Cell migration assay were assessed in AC104041.1 knockdown or combined with miR-6817-3p inhibitors. Data are presented as the mean values ± SD, the experiment was performed in triplicates and repeated three times, *P < 0.05, **P < 0.01 (Student’s t-test). c Cell proliferation were assessed in miR-6817-3p inhibitors or combined with Wnt2B knockdown (n = 5). Data are presented as the mean values ± SEM, the experiment was repeated three times, ***P < 0.001, compared with control cells (two-way ANOVA). d Cell migration assay were assessed in miR-6817-3p inhibitors or combined with Wnt2B knockdown. Data are presented as the mean values ± SD, the experiment was performed in triplicates and repeated three times, *P < 0.05, **P < 0.01 (Student’s t-test). e Immunoblots of indicated proteins in SCC4 cells transfected with AC104041.1 knockdown or combined with miR-6817-3p inhibitors. f Immunoblots of indicated proteins in SCC4 cells transfected with miR-6817-3p inhibitors or combined with Wnt2B knockdown.

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