Fig. 6: pY772-EphA2 is a target of EphA2 inhibitor ALW-II-41-27 in the NPC cells. | Cell Death & Disease

Fig. 6: pY772-EphA2 is a target of EphA2 inhibitor ALW-II-41-27 in the NPC cells.

From: Y772 phosphorylation of EphA2 is responsible for EphA2-dependent NPC nasopharyngeal carcinoma growth by Shp2/Erk-1/2 signaling pathway

Fig. 6

a Western blotting showing the levels of pY772-EphA2, pS897-EphA2, p-Shp2 (Y542/Y580) and p-Erk-1/2 in the EphA2-WT-expressed NPC cells treated with ALW-II-41-27 for 6 h. b Western blotting showing the levels of pY772-EphA2, pS897-EphA2, p-Shp2 (Y542/Y580) and p-Erk-1/2 in the EphA2-SA (S897A)-expressed NPC cells treated with ALW-II-41-27 for 6 h. c–e ALW-II-41-27 inhibits EphA2-WT-expressed NPC cell proliferation. Cells were treated with ALW-II-41-27 and cell proliferation was assayed by CCK-8 (c), EdU incorporation (d), and plate clone formation (e). Numbers represent mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001; ns, no significance.

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