Fig. 4: Aldosterone regulates decidualization through FOXO1.
From: Aldosterone from endometrial glands is benefit for human decidualization
a Immunofluorescent analysis of MR protein after decidual cells were treated with aldosterone and glycyrrhetic acid (Gly acid), respectively. b Western blot analysis of cytoplasmic and nuclear MR protein levels after decidual cells were treated with aldosterone and glycyrrhetic acid. c Effects of aldosterone and glycyrrhetic acid on IGFBP1 expression. d Effects of aldosterone and glycyrrhetic acid on PRL expression. e Effects of aldosterone and glycyrrhetic acid on FOXO1 expression. f Western blot analysis of CREB, FOXO1, and p-CREB protein levels in nuclear fraction of decidual cells. g Western blot analysis on effects of CREB inhibitor (KG-501) on CREB, nuclear FOXO1, and p-CREB. RPL7 was used as internal control for real time PCR and LAMIN A/C as nuclear control for western blot. Gly acid glycyrrhetic acid.
