Fig. 2: Effects of LXA4 on radiation-induced inflammatory response. | Cell Death & Disease

Fig. 2: Effects of LXA4 on radiation-induced inflammatory response.

From: LXA4-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling

Fig. 2

a Total BALF-cell count in mice 2 weeks post-IR. b Representative immunohistochemical images of irradiated lung tissues using anti-CD163 and CD4 antibodies. Magnification, ×40. c IL-1b, CCL8, and CCL2 mRNA expression in irradiated lung tissue measured using quantitative real-time PCR. d IL-1b mRNA expression in MLE12 cells measured using quantitative real-time PCR. e pNF-κB reporter activity in MLE12 cells exposed to 6 Gy IR according to LXA4 dosage. f pNF-κB reporter fold activity in 6 Gy IR-exposed MLE12 cells transfected with or without WRW4. Data are expressed as the mean ± standard error of three independent experiments (*p < 0.05, **p < 0.01, and ***p < 0.001).

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