Fig. 3: LXA4 inhibits IR-induced pulmonary fibrosis at 2 weeks. | Cell Death & Disease

Fig. 3: LXA4 inhibits IR-induced pulmonary fibrosis at 2 weeks.

From: LXA4-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling

Fig. 3

a Representative MT-stained image of mouse lung tissue 2 weeks post-IR (75 Gy) with or without LXA4 in the mouse model (left). Quantification of collagen content (right). Magnification, ×1.25, ×10, and ×40. b Representative immunohistochemical image (left) and quantification (right) of irradiated lung tissues stained with antibodies against IL-6, TGF-β, α-SMA, and Twist. Magnification, ×1.25 and ×40. c IL-6, TGF-β, Col3al, and fibronectin (FN) mRNA expression in the irradiated lung tissue of mice, measured using quantitative real-time PCR. d pSmad reporter activity in 6 Gy IR-exposed MLE12 cells transfected with or without WRW4. Data are expressed as the mean ± standard error of three to five independent experiments (*p < 0.05, **p < 0.01, and ***p < 0.001).

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