Fig. 5: IR reduces LXA4 production. | Cell Death & Disease

Fig. 5: IR reduces LXA4 production.

From: LXA4-FPR2 signaling regulates radiation-induced pulmonary fibrosis via crosstalk with TGF-β/Smad signaling

Fig. 5

a Determination of plasma LXA4 concentration in mice. Plasma samples were collected from mice 2 and 6 weeks post-75 Gy IR and their LXA4 levels were measured by ELISA. b LOX enzyme activity was measured in mice (left) and MLE12 cells (right) using a Lipoxygenase Assay kit, according to the manufacturer’s instructions. ALOX12 and ALOX15 mRNA levels in the irradiated lung tissues of mice (c) and MLE12 cells (d) measured using quantitative real-time PCR. Data are expressed as the mean ± standard error (n = 3‒5, *p < 0.05, **p < 0.01, and ***p < 0.001).

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