Fig. 4: HMBOX1 is negative correlation WTAP expression and is associated to the poor prognosis of osteosarcoma. | Cell Death & Disease

Fig. 4: HMBOX1 is negative correlation WTAP expression and is associated to the poor prognosis of osteosarcoma.

From: WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner

Fig. 4

a The m6A level in HOS and U2OS cells with silenced WTAP. b MeRIP-qPCR assay followed by qRT-PCR revealed the HMBOX1 m6A modification. c Wild-type or m6A site mutant HMBOX1 were cloned in pmirGLO. d Luciferase reporter assays revealed the target role of WTAP on the 3′UTR of HMBOX1. e YTHDF2 expression in osteosarcoma tissue and cells. f The effects of silenced YTHDF2 on HMBOX1 expression in osteosarcoma cells.

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