Fig. 3: Knockdown of CRNDE inhibited tumor growth and lung metastasis in xenograft model. | Cell Death & Disease

Fig. 3: Knockdown of CRNDE inhibited tumor growth and lung metastasis in xenograft model.

From: LncRNA CRNDE facilitates epigenetic suppression of CELF2 and LATS2 to promote proliferation, migration and chemoresistance in hepatocellular carcinoma

Fig. 3

Xenograft tumor model was established by subcutaneously injecting the nude mice with Bel-100 cells transfected with lentiviruses carrying shCRNDE or shNC. a Mice were sacrificed 30 days after injection, tumors were collected and photographed. b Tumor sizes were measured every 5 days. c Tumor weight was compared between shCRNDE and shNC groups. d Tumor xenograft tissues were collected for H&E and IHC staining against Ki67, and representative images were shown. e Lungs were isolated from mice injected with shCRNDE or shNC into the tail veins and photographed. f Pulmonary metastasis nodules from two groups were counted. g Lung tissues were stained with H&E and images were taken under microscope. N = 5 for each group; *P < 0.05.

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