Fig. 6: FBX8 targets HIF-1α, CDK4, and C-Myc to regulates angiogenesis, cell cycle, and proliferation of CRC cells, respectively.
From: FBX8 promotes metastatic dormancy of colorectal cancer in liver
a, b Effects of FBX8 on microvascular formation ability in SW620, SW480, and HT29 cells subcutaneous tumor formation in nude mice detected by IHC. Scale bars represent 20 μm. Data represent mean ± SD. c, d Effects of FBX8 on tube formation in SW620, SW480, and HT29 cells. Scale bars represent 100 μm. Data represent mean ± SD. e The cell cycle of SW620, SW480, and HT29 cell lines. Data represent mean ± SD. f The proliferation of SW620, SW480, and HT29 in vitro detected by Edu. g Effects of FBX8 on apoptosis in SW620, SW480, and HT29 cell lines. Data represent mean ± SD. h Western blot analyses were performed for CD44, SOX-2, and CD133 in SW620, SW480, and HT29 cell lines. i, j Effects of FBX8 on sphere formation rate in SW620 and HT29 cells. Scale bars represent 100 μm. Data represent mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.
