Fig. 6: DNER enhances the tumorigenic ability of BC cells in vivo. | Cell Death & Disease

Fig. 6: DNER enhances the tumorigenic ability of BC cells in vivo.

From: DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer

Fig. 6

a, f, k The transfection efficiency of DNER knockdown or expression in MDA-MB-468, MCF-7 or MDA-MB-231 cells, respectively. b, g The knockdown or overexpression efficiency of DNER in MDA-MB-468 cells or MCF-7 cells, respectively. c, h The xenograft pictures of sh-DNER and NC-DNER in MDA-MB-468 cells (n = 5). d, i Comparison of tumour weights from various groups. (e, j) The expression of DNER and β-catenin in xenograft tissue by western blotting. h The xenograft pictures of NC-DNER group, OE-DNER group and OE-DNER treated with XAV-939 group in MCF-7 cells (n = 3). l Schematic diagram of in vivo experimental procedure for lung metastasis potential in situ of BC. m Bright imaging of the lungs metastasis (left) and quantification of the metastases tumour (right) generated by MDA-MB231 cells (n = 5). **p < 0.01 vs the corresponding group.

Back to article page