Fig. 4: Effects of ELA on the DOCA/salt-induced activation of NLRP3 inflammasome. | Cell Death & Disease

Fig. 4: Effects of ELA on the DOCA/salt-induced activation of NLRP3 inflammasome.

From: ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway

Fig. 4

a Representative immunoblots of NLRP3 and cle-Casp-1 in renal cortex and medulla as well as summarized intensities of blots. b NLRP3 mRNA levels in the renal cortex and medulla. c mRNA levels of IL-1β, IL-18, and MCP-1 in the renal cortex and medulla. N = 6 per group. *P < 0.05 versus Ctrl group; #P < 0.05 versus DOCA/Salt group. NLRP3 Nod-like receptor protein 3, cle-Casp-1 cleaved Caspase-1, IL-18 Interleukin-1β, MCP-1 monocyte chemotactic protein 1.

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