Fig. 8: Effects of ELA deficiency on DOCA/salt-induced hypertension and potential mechanism of ELA exerted on DOCA/salt-induced hypertension. | Cell Death & Disease

Fig. 8: Effects of ELA deficiency on DOCA/salt-induced hypertension and potential mechanism of ELA exerted on DOCA/salt-induced hypertension.

From: ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway

Fig. 8

a The mRNA level of ELA in the kidney of heterozygous ELA knockout C57BL/6 mice (ELA+/−) compared to WT ones. N = 5. b Systolic blood pressure (SBP). c Potential mechanism of ELA exerted on DOCA/salt-induced hypertension. In DOCA/salt-treated kidney, ELA blocks the NADPH oxidase formation by inhibiting the expression of its subunits p22phox, gp91phox, p47phox, and p67phox; decreases the ROS production; obstructs the recruitment and activation of NLRP3 inflammasome; attenuates hypertension and renal injury. *P < 0.05 versus WT Ctrl group. #P < 0.05 versus DOCA/salt-treated WT group.

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