Fig. 6: Cathepsin B inhibition and ROS clearance reversed Tub-induced apoptosis in lung cancer cells. | Cell Death & Disease

Fig. 6: Cathepsin B inhibition and ROS clearance reversed Tub-induced apoptosis in lung cancer cells.

From: Tubeimoside I-induced lung cancer cell death and the underlying crosstalk between lysosomes and mitochondria

Fig. 6

a The apoptosis rate of NCI-H1299 cells after treatment with Tub at the indicated concentrations, as demonstrated by Annexin-V/PI staining and flow cytometry analysis. b The cleaved forms of PARP and Caspase 3 were upregulated in lung cancer cells following Tub treatment. c The cathepsin B inhibitor, in part, reversed the apoptosis in NCI-H1299 cells treated with Tub (the treatment details can be found in Fig. 5). d NAC (a ROS scavenger), in part, rescued the Tub-induced apoptosis in NCI-H1299 cells. *p < 0.05, **p < 0.01, ***p < 0.001 vs. the indicated groups.

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