Fig. 2: Rheb-induced activation of mTORC1 in Neuropathic pain and block the mTORC1 signal with rapamycin alleviate the development of neuropathic pain. | Cell Death & Disease

Fig. 2: Rheb-induced activation of mTORC1 in Neuropathic pain and block the mTORC1 signal with rapamycin alleviate the development of neuropathic pain.

From: Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain

Fig. 2

a, b, c Western blot analysis of spinal cord to assess the activation of mTORC1 signal in sham mice and mice with CCI of the sciatic nerve after 7 days, CCI obviously increase the phosphorylation of spinal mTOR, S6 and 4-EBP1 (n = 6 for all groups); d CCI-induced phosphorylation of spinal S6 in the dorsal horn (n = 5); e CCI-induced phosphorylation of S6 co-immunostaining with neuron (left, NeuN in green), but nont astroglia (middle, GFAP in green), or microglia (right, CD11b in green) in the spinal dorsal horn, scale bars = 50 μm. Student’s t test (a, b, c, d). *P < 0.05. Error bars are mean ± SEM. Overlaid points are individual animal scores.

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