Fig. 7: Madecassic acid alleviates colitis through inhibiting the activation of γδT17 cells dependent on PPARγ. | Cell Death & Disease

Fig. 7: Madecassic acid alleviates colitis through inhibiting the activation of γδT17 cells dependent on PPARγ.

From: Inhibition of the activation of γδT17 cells through PPARγ–PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid

Fig. 7

Colitis was induced in female C57BL/6 mice by drinking with 2.5% dextran sulfate sodium (DSS) for 7 days, and followed by normal drinking water for 3 days. Madecassic acid (MA, 25 mg/kg), cyclosporin A (CsA, 25 mg/kg), or GW9662 (1 mg/kg) were orally administered for 10 days consecutively. a The representative flow cytometry and percentages of IL-17A+ subpopulations present in the γδTCR+ T cells from the colon tissues of mice. b The levels of IL-17A as assessed by enzyme-linked immunosorbent assay. c The expression level of Il17a as assessed by real-time PCR. d Disease activity index (DAI). e Colon length. f Myeloperoxidase (MPO) activity. g Hematoxylin and eosin (H&E) staining (scale bar, 100 μm). The data are expressed as means ± SEM of six mice per group. *P < 0.05, **P < 0.01 versus the indicated group.

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