Fig. 3: BAX/BAK DKO hiPSCs and hNPCs have abnormal mitochondrial morphology, despite having no difference in mitochondrial function.
From: Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems
a TOM20 and anti-mitochondria staining in hiPSCs control and DKO shows loss of mitochondrial morphology in DKO. Scale bar = 10 µm. b Quantification of volume with TOM20 staining in hiPSC and hNPC lines. c Quantification of volume with anti-mitochondria staining in hiPSC and hNPC lines. d Quantification of counts using TOM20 staining in hiPSCs and hNPCs. e Quantification of counts using anti-mitochondria in hiPSCs and hNPCs. f hNPCs stained with TOM20 and anti-mitochondria show loss of mitochondrial morphology in DKO. Scale bar = 10 µm.
