Fig. 2: Depletion of LINC01106 attenuates the malignant phenotypes of CRC cells. | Cell Death & Disease

Fig. 2: Depletion of LINC01106 attenuates the malignant phenotypes of CRC cells.

From: LINC01106 drives colorectal cancer growth and stemness through a positive feedback loop to regulate the Gli family factors

Fig. 2

a Colony-forming ability of LoVo and SW1116 cells was assessed after loss of LINC01106. b EdU assay revealed the proliferative ability of LoVo and SW1116 cells in response to silencing of LINC01106. c Transwell migration assay in LoVo and SW1116 cells transfected with sh-LINC01106 or sh-NC. d Western blot assay of the levels of migration-related proteins (MMP2 and MMP7) and EMT markers (E-cadherin and N-cadherin) in response to LINC01106 blockade. e and f The expression of stemness markers (NANOG and OCT4) was analyzed via qRT-PCR and western blot after LINC01106 depletion. g Sphere formation of LINC01106-silenced cells was analyzed compared with sh-NC group cells. Data shown as mean ± SD were collected from three independent experiments. **P < 0.01 indicated data had statistical significance.

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