Fig. 3: Conditioned medium of irradiated organoids reduces self-renewal potential of salivary gland stem/progenitor cells. | Cell Death & Disease

Fig. 3: Conditioned medium of irradiated organoids reduces self-renewal potential of salivary gland stem/progenitor cells.

From: Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche

Fig. 3

a Schematic overview of the study design. b Representative images of passaged day 7 (D7) organoids cultured in fresh, C50% and IR50% medium and their c organoids formation efficiency (OFE). Medium was collected at D12 and mixed with fresh medium in a 1:1 ratio, resulting in control (C50% medium) and IR (IR50% medium) conditioned medium. Scale bar, 200 μm. N = 3/group, *p < 0.05; ns not significant, Wilcoxon signed-rank test.

Back to article page