Fig. 2: BMP4 Tg expression re-activates Smads. | Cell Death & Disease

Fig. 2: BMP4 Tg expression re-activates Smads.

From: Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects

Fig. 2

a Protein levels of phosphorylated Smad1/5/8 and Smad1/5/8 in E8.5 non-BMP4 Tg and BMP4 Tg embryos from nondiabetic (ND) or diabetes mellitus (DM) dams. Quantification of relative expression levels of phosphorylation of Smad1/5/8 versus total Samd1/5/8 was shown in the graphs. b Protein levels of Smad4 in E8.5 non-BMP4 Tg and BMP4 Tg embryos from nondiabetic (ND) or diabetes mellitus (DM) dams. Quantification of relative expression levels of Smad4 was shown in the graphs. Experiments were performed using three embryos from three different dams per group (n = 3); * indicates significant difference compared to the other groups (P < 0.05) in one-way ANOVA followed by Tukey tests. ND: nondiabetic; DM: diabetes mellitus.

Back to article page