Fig. 1: Absence of HOPS affects pro-inflammatory gene transcription.
From: HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6
Hops−/− cells are less responsive to LPS stimulation. Time course of mRNA expression of Il-6, Il-1β, and Tnfα after LPS stimulation (10 µg/ml) for the indicated times (hours, h) in Hops+/+ and Hops−/− bone marrow derived macrophages (BMDMs), measured by qPCR. Values are normalized to 18S housekeeping gene. Graphs show fold changes in gene expression compared with unstimulated cells. All the values are the mean ± SD (n = 3 mice). Statistically significant changes are shown.
