Fig. 1: Docking study and anti- angiogenesis effect of ZJQ-24. | Cell Death & Disease

Fig. 1: Docking study and anti- angiogenesis effect of ZJQ-24.

From: Indole hydrazide compound ZJQ-24 inhibits angiogenesis and induces apoptosis cell death through abrogation of AKT/mTOR pathway in hepatocellular carcinoma

Fig. 1

A Chemical structure of ZJQ-24. B Compound ZJQ-24 docked into mTOR based on PDB code 4JT6, AKT based on PDB code 3O96. C The binding energies between ZJQ24 and proteins (mTOR, AKT and VEGFR2). D Tube formation inhibition. HUVECs were seeded on the surface of the Matrigel and treated with or without ZJQ-24. After incubation for 6 h, capillary tube formation was examined using an inverted microscope. *P < 0.05, **P < 0.01 vs. control group.

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