Fig. 8: A working model of miR-322/-503 in DM1. | Cell Death & Disease

Fig. 8: A working model of miR-322/-503 in DM1.

From: miR-322/-503 rescues myoblast defects in myotonic dystrophy type 1 cell model by targeting CUG repeats

Fig. 8

miR-322/-503, required by normal myoblast differentiation, was downregulated in DM1 myoblast differentiation and patient serums. Ectopic miR-322/-503 expression rescued myoblast differentiation defects, ribonuclear foci, and aberrant alternative splicing in DM1 myoblast mainly through targeting the expanded CUG repeats. Meanwhile, Celf1 as an alternative miR-322/-503 target only accounts for the partial rescue of myoblast differentiation defects. This figure was drawn with Pathway Builder 2.0.

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