Fig. 7: Proliferation, angiogenesis and apoptosis assays in vivo. | Cell Death & Disease

Fig. 7: Proliferation, angiogenesis and apoptosis assays in vivo.

From: Synergetic therapy of glioma mediated by a dual delivery system loading α-mangostin and doxorubicin through cell cycle arrest and apoptotic pathways

Fig. 7

a Ki67 staining was performed in tumor tissue sections of different groups to visualize tumor proliferation. CD31 staining was applied to analyze tumor angiogenesis. TUNEL staining was conducted to study tumor apoptosis. H&E staining was used to observe cell morphology. b The average percentage of Ki67-positive cells. c The average percentage of CD31-positive vessels. d The average percentage of TUNEL-positive cells. The tumor specimens were from the C6 subcutaneous model. Data are representative of at least three independent experiments. n = 5; *p < 0.05, **p < 0.01, ***p < 0.001; ANOVA and Student’s t-test.

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