Fig. 7: A schematic diagram explaining the role of sPD-L1 in direct ARDS.
From: Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages
In the setting of direct ARDS, soluble PD-L1 binded to the monocytederived dmacrophages with increased PD-1 expression and induced their apoptosis. The reduced MDMs alleviated the inflammatory lung injury and ultimately improved direct ARDS.
