Fig. 8: circ-CBFB knockdown attenuates APAP-induced mitochondrial dynamics perturbation and liver injury in mice via miR-185-5p.
From: circ-CBFB upregulates p66Shc to perturb mitochondrial dynamics in APAP-induced liver injury
circ-CBFB and miR-185-5p silencing was induced via lentiviruses delivered to C57BL/6 mice exposed to APAP. a H&E staining. Scale bar, 200 μm. b, c Mitochondrial dynamics perturbation was determined via TEM (×2000/×10,000, magnification, red arrow). d Serum ALT levels, n = 8. e Serum AST levels, n = 8. f Liver GSH levels, n = 8. g Liver MDA levels, n = 8. h, i Liver p66Shc, OMA1, S-OPA1, MFN2, DRP1, and p-DRP1 proteins, n = 3. **p < 0.01 vs. the LV-control group; ##p < 0.01 vs. the APAP group; &p < 0.05, &&p < 0.01 vs. the LV-CBFB group.
