Fig. 4: TLR4 and FcγR signaling were responsible for regulating M2b macrophages in vivo. | Cell Death & Disease

Fig. 4: TLR4 and FcγR signaling were responsible for regulating M2b macrophages in vivo.

From: Tumor necrosis factor α inhibition overcomes immunosuppressive M2b macrophage-induced bevacizumab resistance in triple-negative breast cancer

Fig. 4

a–b Tumor growth volume and photos over time following subcutaneous transplant of tumor tissues into wild type and (TLR4lps–del) mut/mut C57BL/10 mice. n = 5 for each condition. **P < 0.01; ***P < 0.001 by two-way ANOVA test. Error bars represent s.d. c Quantitative evaluation of CD31 in each tumor of mice (IOD/Area). **P < 0.01 by t test. Error bars represent s.d. d–e Representative images and quantitative evaluation of double staining for CCL1 and nucleus. Scale bar, 200 μm. ***P < 0.001; ****P < 0.0001 by t test. Error bars represent s.d. f Quantitative evaluation of CD68 in each tumor of mice (IOD/Area). **P < 0.01 by t test. Error bars represent s.d. g Quantitative evaluation of CD86 in each tumor of mice (IOD/Area). **P < 0.01 by t test. Error bars represent s.d.

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