Fig. 2: IL-22 protects mice against LPS-induced acute liver injury.
From: IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling
Mice were divided into control (Control), LPS-treated (LPS), IL-22 only (IL-22), and IL-22 pretreatment for 4 days before LPS administration (IL-22+LPS) groups (n = 6). a Serum IL-22 levels in mice with (IL-22) or without IL-22 pre-treatment (Control). b Serum levels of ALT. c Serum levels of AST. d Liver sections were stained with hematoxylin and eosin (H&E staining) at 48 h after LPS stimuli. e Serum levels of IL-6. f The mRNA levels of TNF-α in livers. g The mRNA levels of IL-1β in livers. h The mRNA levels of IL-6 in livers. * indicates the significant difference compared with Control group, p < 0.05. # indicates the significant difference compared with LPS group, p < 0.05.
