Fig. 1: Endoplasmic reticulum (ER) and mitochondria destruction in human acute pancreatitis (AP) and chronic pancreatitis (CP) tissues accompanying with elevated apoptosis.
From: EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis
A Histological evaluation of human healthy, AP and CP pancreatic tissues by haematoxylin and eosin (H&E) staining and histological score. Pancreas sections from AP patients were stained for myeloperoxidase (MPO) (B) while CP tissues were stained for Masson’s trichrome (C). D The microstructure of human healthy, AP and CP pancreatic tissues were observed by transmission electron microscopy (TEM); black arrows (↑): cell nucleus; white arrows (↑): endoplasmic reticulum; blue arrows (↑): zymogen granule; purple arrows (↑): mitochondria; red arrows (↑): apoptotic body; yellow arrows (↑): mesenchyme. E The expression of apoptosis related proteins Caspase-3 and PARP (poly ADP-ribose polymerase) in human pancreatic tissues (including normal, AP and CP) were analyzed. AP acute pancreatitis, CP chronic pancreatitis. Data represents the mean ± SD; *P ≤ 0.05, **P ≤ 0.01. Scale bars = 100 μm.
